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Scientific References

  • 1.Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models.

    https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000307

  • 2.Wilson BS, Tucci DL, Merson MH, O'Donoghue GM. Global hearing health care: new findings and perspectives. Lancet. 2017;390(10111):2503–15.

    https://pubmed.ncbi.nlm.nih.gov/28705460/

  • 3.Nondahl DM, Cruickshanks KJ, Huang GH, Klein BE, Klein R, Nieto FJ, et al. Tinnitus and its risk factors in the Beaver Dam offspring study. Int J Audiol. 2011;50(5):313–20. pmid:21309642; PubMed Central PMCID: PMCPMC3073029.

    https://pubmed.ncbi.nlm.nih.gov/21309642/

  • 4.Yang S, Weiner BD, Zhang LS, Cho SJ, Bao S. Homeostatic plasticity drives tinnitus perception in an animal model. Proc Natl Acad Sci U S A. 2011;108(36):14974–9. Epub 2011/09/08. 1107998108 [pii] pmid:21896771.

    https://pubmed.ncbi.nlm.nih.gov/21896771/

  • 5.Li S, Choi V, Tzounopoulos T. Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus. Proc Natl Acad Sci U S A. 2013;110(24):9980–5. pmid:23716673.

    https://pubmed.ncbi.nlm.nih.gov/23716673/

  • 6.Li S, Kalappa BI, Tzounopoulos T. Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus. Elife. 2015;4. pmid:26312501; PubMed Central PMCID.

    https://pubmed.ncbi.nlm.nih.gov/26312501/

  • 7.Kotak VC, Fujisawa S, Lee FA, Karthikeyan O, Aoki C, Sanes DH. Hearing loss raises excitability in the auditory cortex. J Neurosci. 2005;25(15):3908–18.

    https://pubmed.ncbi.nlm.nih.gov/15829643/

  • 8.Abbott SD, Hughes LF, Bauer CA, Salvi R, Caspary DM. Detection of glutamate decarboxylase isoforms in rat inferior colliculus following acoustic exposure. Neuroscience. 1999;93(4):1375–81. pmid:10501462.

    https://pubmed.ncbi.nlm.nih.gov/10501462/

  • 9.Milbrandt JC, Holder TM, Wilson MC, Salvi RJ, Caspary DM. GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma. Hear Res. 2000;147(1–2):251–60. pmid:10962189.

    https://pubmed.ncbi.nlm.nih.gov/10962189/

  • 10.Jastreboff PJ, Brennan JF, Coleman JK, Sasaki CT. Phantom auditory sensation in rats: an animal model for tinnitus. Behav Neurosci. 1988;102(6):811–22.

    https://pubmed.ncbi.nlm.nih.gov/3208067/